Leukemia myeloid matuitui

Matuitui leukemia - o se faamaʻi o le faiga hematopoietic, e faavae i luga - o le proliferation faatapulaaina o sela patu, o lona substrate morphological. Matuitui leukemia myeloid i faavasegaina FAB ua vaevaeina i ni filifiliga e fitu. O le faavae o le faavasegaina - o le tulaga o le eseesega o le sela ma sui o le leukemia substrate. e maua Myeloblasts clone patu mai sela pogai, lea e mafai ona fua kolone faatupulaia le aofai o sela myeloid, megakaryocytes, erythrocytes, macrophages.

Sili ona matauina soo variants M0-M3. O le faavae o le muamua e lua - sela e aunoa ma eseesega. differentsirovanokletochny - m 2 filifiliga. e faamatalaina M3 embodiment promyelocytic e faaletonu sela e fatu tetele. M4 ma M5 - myeloblastic leukemia ma monoblastny. M6 - erythromyelosis, o le faateleina proliferation o sela erythroid. M7 - leukemia megacaryoblastic. O filifiliga uma, lea ua tuuina atu i leukemia myeloblastic matuitui, e sili ona lelei vāloʻaga pe M0-m 2.

leukemia etiopathogenesis

O le a leukemia myelogenous matuitui. Le faamai - faaleleia atili tomai o sela e mutations ona o le faatinoga o le itu i fafo atu (leisa, siama, mea vailaau) ma predisposition e le mautu tau kenera o le genome. Lea ua iʻu ai i le sela patu mafai ona vaega faatapulaaina. Latou fausia se clone lea, i le taimi, e ala i soo mutations e siitia ai subclones.

ua gaosia e faaauau pea sela patu i le su le ivi, ma faamalosia leaga hematopoiesis siama e masani ai. Na faasolosolo malie, ona latou o atu i le toto peripheral ma metastasize e totoga, ua avea foci faaopoopo o faʻalavelave hematopoiesis. Atiina ae o leukemia myeloid ma ata togafitiga uiga mo ia.

Falemai leukemia myelogenous matuitui

Ona o le faatamaiaina o le hematopoiesis masani i gasegase ma anemia, o le aofai o neutrophils ma platelets matua faaitiitia malosi. dizziness popole. vaivaiga. Loo i ai faailoga o le toto: hemorrhages i le membranes paʻu ma mucous, faateleina tafetotoi i maʻimāsina, nosebleeds. Tiga i le ivi, fulafula nodes lymph o vaega eseese. atepili ma ate faateleina. Ona faaletonu galuega tauave a leukocytes, faaitiitia puipuiga mausali tupe leukemia myeloblastic matuitui pipisi accession. e masani ona ia faaalia angina ogaoga.

I le vaega mulimuli ane e mafai ona faailoga faapipii o fatugaʻo le toilalo ma le auga neurological.

I lona tafe leukemia myeloblastic matuitui faalautele laasaga faaaliga deployed, faamagaloga, toe tupu. I le tulaga o aoga togafitiga ua iʻu ai i le tulaga tigaina. Tulaga o le faamai faamatalaina e nisi auga togafitiga ma le toto ata ma le su ivi.

auga o leukemia

Matuitui leukemia myeloid ua faia e suesuega cytochemical sela fai ma sui o lona substrate ma immunophenotyping - fuafuaina faailoga myeloid. Morphological metotia mo le mauaina o faa- taʻutaʻu sela i le fuafuaina o le ituaiga o leukemia ua tuuina atu se taua faailoga lea, e ui lava latou faaauau pea ona fiafia i ai.

O nisi taimi e faaaoga metotia genotypic faavae i tali filifili polymerase. O loo faaaogaina e iloa ai le faaaliga residual o le faamai i le gasegase i le faamagaloina.

Matuitui vāloʻaga leukemia myelogenous itiiti ifo le lelei nai lo le vāloʻaga o leukemia matuitui lymphatic. E oo atu i le 75% o le gasegase ma togafitiga talafeagai ausia faamagaloina. O loo i ai molimau o le faamalologa o le 20% faamagaloina ausia ma faaauau togafitiga matuai. O taunuuga faamalosiau o loo maua e ala i transplantation su ivi.