Inhibitors Cholinesterase: o le faaaogaina o pharmacological

E iloa o loo i ai le tele o synapses neura. e tatau ai i latou mo le auina atu o uunaiga. O lenei faiga e aofia ai le tele o ituaiga o puluvaga. I totonu oi latou, - .., Acetylcholine, norepinephrine, Kipea, serotonin, ma isi o puluvaga (masini) e manaomia mo le faaliliuina atu o le faailoga i le va o neurons. Gata i lea, e tatau ai ia i latou e tauaveina excitation po musculature inhibition. I pathologies eseese o le galuega popole faiga neurotransmitters mafai ona solia. Tupu lenei mea i gaioiga atrophic ma degenerative i le faiai. I nei tulaga, faaaogaina o fualaau oona e manaomia mo amplifying po attenuating le faailo faasalalauga. E se vaega pharmacological faapena e inhibitors cholinesterase. o loo faaaogaina i latou i myasthenia, neuritis, amyotrophic sclerosis lateral, faamaʻi o le Alzheimer, pathologies le mafaufau.

Taunuuga o le inhibitors cholinesterase

inhibitors Cholinesterase - o se vailaau ua lautele faaaogaina i neurology ma le mafaufau. O loo vaevaeina i ni nai vaega, taitasi lea o le o talafeagai i se mataupu faapitoa. O le faatinoga o nei fualaau faasaina galue e ala i polokaina cholinesterase. O lenei enzyme e maua e le gata i tagata soifua maloloina ma latou o loo mafatia mai faamai eseese. E tatau ona soloia ai i lalo neurotransmitter - acetylcholine. O se taunuuga o ana gaoioiga transmitter faʻaleagaina e choline ma acid acetic. I pathologies eseese o atrophy le cortex faiai lava ina faasolosolo malie. O se taunuuga, o nisi fausaga e mafai ona pau atoatoa, e aofia ai le faiga cholinergic. E le gata i atrophy faiai, e tau atu i lenei faagasologa degenerative o autoimmune, pipisi, natura viral. Ona o le faaumatiaga o le nuclei forebrain loo i ai se leai faaleoina o neurotransmitter - acetylcholine. O le umi e mafai ai sa leai se le lava o le mea, e tatau ona galue i luga o le enzyme e lepetia ai. Mo lenei faamoemoe, o loo faaaogaina le inhibitors cholinesterase. Faafetai atu ia i latou, e mafai ona faaauau pea gaoioiga neurotransmitter mo ni nai tausaga.

inhibitors Cholinesterase: fualaau faasaina faavasegaina

E tele ni ituaiga o fualaau oona anticholinesterase. Ua faavasega i latou e tusa ma le aafiaga pharmacological i le enzyme. O nisi oi latou o loo polokaina cholinesterase foia, isi - tumau. Faasoasoa 3 vaega medicaments. Faatasi ma i latou:

1. blockers feliuai. O nei inhibitors cholinesterase galue i signaling postsynaptic. Faafetai ia i latou, e faalavelaveina mo sina taimi le enzyme. O lenei vaega e aofia ai acridines ma piperidine.
2. Psevdoneobratimye blockers cholinesterase. O la latou auala o le faatinoga o faatasi ma vaega onionovoy o le molecule enzyme. I le gata i lea, e mafai ona latou fusifusia i le receptors acetylcholine. O nei meatotino o se vaega o carbamates.
3. inhibitors foia o cholinesterase. O lenei vaega o fualaau faasaina taʻua o organo-phosphates auala. Sui o le a medicament "Metrifonate".

O le vaega o acridines aofia ai le "feaveai ai vaalele" o fualaau faasaina ma le "Velnakrin". Sui carbamates - vailaau "rivastigmine", "Epistatigmin".

Faailoga mo le faaaogāina o inhibitors cholinesterase

o loo faaaogaina inhibitors Cholinesterase e taulimaina faamaʻi musele o tupuaga tutotonu, atrophy ma faaletonu faiai degenerative. I le faaopoopo atu, e maua ai nisi o vailaau i le tulaga o mataua. o loo faaaogaina i latou i uunaiga intraocular siitia - glaucoma. Fualaau faasaina o loo taofiofia cholinesterase feliuai, faailoa mo le togafitia o gasegase o le mafaufau, filifiliga a le faamaʻi ma le Alzheimer. Faamuamua o le tuuina atu vaega piperidine, talu ai oi latou o ni filifili ma aafiaga itiiti itu. I tausaga talu ai nei, faateleina le faailoga mo le faaaogaina o fualaau faasaina. ua tatau ona totogi lenei i se suesuega auiliili o le latou meatotino. Mo faamai i ai le fualaau faasaina anticholinesterase faatonuina aofia myasthenia gravis, atony intestinal, dystrophy muscular, amyotrophic sclerosis lateral, o le supa o lala amataga degenerative. o loo faaaogaina inhibitors foia i tulaga o ona i.

Contraindications i le faaaogāina o fualaau faasaina cholinesterase

Fualaau i lenei vaega e le o faaaogaina i le faaletonu convulsive, hyperkinesis o so o se etiology. ua contraindicated i gasegase ma foi ona latou toilalo ogaoga loto, sela, thyrotoxicosis. E le manaomia e anticholinesterases ma papala gastric concomitant, enteritis. e le o faaalia vailaau i tamaitai maitaga ma lactating.

inhibitors Cholinesterase: o le filifiliga o fualaau faasaina mo le faamaʻi o le Alzheimer

faamai o le Alzheimer - o atrophic CNS, lea o loo i ai aminesia, uiga le atoatoa ma le gasegase o le mafaufau. Saienitisi i le lalolagi o loo taumafai e saili se fofo mo lenei faamaʻi. I mamafa agamalu ma feololo o le faamai o le fualaau faasaina o le filifiliga "donepezil". E faasino atu i se inhibitor feliuai cholinesterase, ei ai se aafiaga filifili. O se vailaau e faaaoga mo le faamoemoe o le togafitiga pathogenetic. E le o mafai e faamalolo atoatoa ai le onosai, ae slows le atinae o auga faamaʻi o le Alzheimer.