Fualaau faasaina Antileukotriene o le tupulaga fou: a lisi o le mea sili

fualaau faasaina Antileukotriene fai ma sui o se vasega fou o le sui o le faaitiitia o le faagasologa inflammatory e etiology allergic po pipisi.

Ina ia malamalama i le mataupu faavae o faatinoga o nei fualaau oona, e tatau ona malamalama i le mea o le leukotrienes.

leukotrienes

O i latou o puluvaga o Fula. Tusa ma o latou fausaga vailaau, latou acids puta, ua faia o acid arachidonic.

ua aafia Leukotrienes i le atinae o le sela. Faapea foi histamine, ua latou o puluvaga o tali allergic o le ituaiga vave. Histamine mafai ona mafua ai se bronchospasm mo se taimi puupuu vave ae ma leukotrienes mafua tuai ma toe spasm.

E pei ona faavasegaina fualaau faasaina antileukotriene?

Le taimi nei, ua faavasegaina leukotrienes e faapea: A _4, B _4, F _4, D _4, E _4.

Tuufaatasia o leukotrienes maua mai acid arachidonic. O lalo o le uunaiga o tupe 5-lipoxygenase e leukotriene A _4. Ina ua mavae lena o loo i ai se tali cascade, lea na oo i le leukotrienes pepa nei B ₄ -C ₄ -D ₄ -E _4. Le oloa mulimuli o lenei tali - LTE _4.

Faavaeina e LTE _4, D _4, E ₄ mafai ona mafua ai aafiaga bronchoconstrictor, e mafai ona saofaga i le faateleina o vavale secretion le atinae o edema, taofiofia le kiliaina mucociliary.

B _4, D _4, E ₄ gaoioiga chemotactic, i.e. e ono tosina neutrophils ma eosinophils i le sone faagasologa inflammatory.

Saienitisi ua faaalia ai, e maua e ala i macrophages leukotrienes, sela pou, eosinophils, neutrophils, T-lymphocytes, ua aafia tuusao i tali inflammatory. fualaau faasaina Antileukotriene i sela e masani ona faaaoga.

Ina ua mavae le sela oo mai i se fesootaiga ma se allergen ma cooling tupu airways po o le tuanai faamalosi tino, faagaoioia TUTU tuufaatasia. O lena mea, e amata ai le tuufaatasia pe a le osmolarity o faateleina mataupu bronchial.

E fa vaega o fualaau faasaina

Ua iloa nei i fualaau faasaina antileukotriene vaega uma e fa:

1. "Zileuton", o se inhibitor tuusao o 5-lipoxygenase.
2. Formulations ua inhibitors floppy, lapataiga faagasologa o le noatia ai le porotini ma acid arachidonic.
3. "Zafirlukast", "Pobilukast", "Montelukast", "pranlukast", "verlukast" lea e tagata tetee o receptors leukotriene sulfidopeptidnyh.
4. Fualaau faasaina e tagata tetee o leukotriene B ₄ receptor.

Sili ona suesueina e antileukotriene fualaau faasaina o le vaega muamua ma le vaega lona tolu o le tupe. Mafaufau i nei vaega i auiliili.

"Zileuton"

"Zileuton" o se inhibitor feliuai o 5-lipoxygenase. E mafai ona ia taofiofia le faavaega sulfidopeptidnyh le TUTU ma RT _4. mafai ona tumau ai aafiaga bronchodilator le fualaau faasaina i le lima itula. Foi e mafai ona taofia ai le tulai mai o spasm bronchial, o se taunuuga o le aafia i le malulu ea po o le "asipirini".

e faamaonia suesuega tele "Zileuton" tofia e gasegase mafatia mai sela bronchial mo se tasi i le ono masina, e mafai ona faaitiitia ai le manaomia o le onosai i inhaled β2-agonists ma corticosteroids. O se tasi inumaga "zileuton" lapatai le tulai mai o sneezing ma shortness o le manava nasal i gasegase oe mafatia mai allergic rhinitis ina ua uma pulega nasal o allergen.

O togafitiga e ono vaiaso i le "zileuton" sela atopic faaalia se taunuuga taua. Fai mai fomai tuuina i lalo sili ona lelei o eosinophils ma neutrophils. Foi, e faaitiitia vaega necrosis patu i vai lavage bronchoalveolar ina ua mavae tofotofoga ituaiga allergen. O le mea lena o fualaau faasaina antileukotriene tulaga ese, ua faavae ai le faiga o le gaoioiga i lenei.

"Zileuton" e faamatalaina i se taimi puupuu, i le taimi lea o loo i ai lona afa o le olaga. O lenei e taʻu mai ai e tatau ona faia soo lava le fualaau faasaina i le faafa i le aso. I le faaopoopo atu, "Zileuton" e mafai ona faaitiitia le kiliaina o theophylline. E tatau ona manatu, pe afai ua manatu tutusa mauaina theophylline ma "zileuton". O lona uiga, e tatau ona faaitiitia le inumaga muamua. Afai "Zileuton" ua tofia se taimi umi, e talafeagai ai e mataituina le tulaga o enzymes ate.

Ae o loo i antileukotriene tupulaga fou o fualaau oona, latou lisi ua faaalia i lalo.

Sui lea e tagata tetee o leukotrienes sulfidopeptidnyh, tauva e maualuga blockers filifili ma feliuai TUTU D ₄ receptors. O nei fualaau faasaina e aofia ai "pranlukast" "Zafirlukast", "Montelukast."

"Akolat" ( "Zafirlukast")

"Zafirlukast" aka "Akolat" e sili ona suesueina o lenei vaega o antileukotriene mea o fualaau faasaina. E foi ni aoaoga faamasani bronchodilator toaaga. O le aafiaga umi lava se taimi umi, e oo atu i le lima itula. "Zafirlukast" faagasologa e mafai ona ia taofia ai le atinae o se tali asthmatic i le tulaga o le manavaina i totonu allergen. ua faamaonia lona aoga, ma le spasm bronchial puipuiga, lea e faatupuina e le ea malulu, asipirini, gaoioiga faaletino, filogia. fualaau faasaina Active, ma sauniuniga "Montelukast" mafai ona faaleleia ai le gaoioiga bronchodilator o β2-agonists.

"Akolat" ( "Zafirlukast") i ai absorbability lelei, o lona faasalaga tumutumu i le toto ua ausia ina ua mavae le tolu itula ina ua uma lona pulega. O lona vaitaimi o le afa o le olaga o si umi atu nai lo le "zileuton", ma o le 10 itula. I le faaopoopo atu, e leai se aafiaga i luga o le kiliaina o theophylline. Talia e tatau ona avea o fualaau oona toaaga pe o se itula i luma o le taumafataga po o totonu o le lua itula mulimuli ane, talu mai le tele faaititia ai le meaai lona tulaga gafatia mitiia. O lona uiga o le taliaina lelei lava.

iʻuga

e mafai ona faaaoga Antileukotriene fualaau faasaina mo allergies mo tamaiti, ae o le taimi ua latou oo atu i le tausaga e lua. Faatasi ai ma le fesoasoani a nei fualaau i fanau taulimaina ma bronchitis faifaipea, rhinitis allergic, sela agamalu.